BIO4 Engineering Biosynthetic Pathways in Drug Discovery

Naturally produced polyketides and non-ribosomal peptides possess a broad range of important biological activities and have the potential to be developed into potent pharmacological drugs. The assembly of these natural products has been the subject of intensive protein engineering efforts to produce tailored and improved analogues that perform desired biological activities. In this lecture a researcher from Isomerase Therapeutics Ltd will discuss strategies to modify the production lines of modular biosynthetic systems introduced in the previous lecture, and will present the concepts used to create 'designer' natural products that act as pharmacological agents, using real-life examples from Isomerase's portfolio.