Chemistry: Graduate Lecture Series: (CA6) Asymmetric Homogeneous Hydrogenation in the Synthesis of APIs (1L)

CATALYSIS (CA)

(CA6) Asymmetric Homogeneous Hydrogenation in the Synthesis of APIs (1L)

Course Presenter: Dr Antonio Zanotti-Gerosa (Johnson Matthey)

Homogeneous hydrogenation and transfer hydrogenation are recognised as powerful tools for the industrial production of chiral intermediates. The talk, much based on the personal experience of the author, will provide a brief overview of the historical development of this area, a discussion on the scope and limitations of the technology and its complementarity with other technologies (e.g. biocatalysis, heterogeneous catalysis), a discussion on the key parameters affecting the economic viability of industrial asymmetric hydrogenation processes and an outlook on future research directions. Several case studies of projects developed by Johnson Matthey, Catalysis and Chiral Technologies with industrial customers will be reported.

Postgraduates in the Department of Chemistry

Lecture

1 hour