skip to navigation skip to content

Reset

Filter by

Course type

Show only:



Dates available




Places available




Theme









Filter search

Browse or search for courses


Showing courses 1-10 of 33
Courses per page: 10 | 25 | 50 | 100

Process systems engineering (PSE) is a developed field of engineering, focusing on mathematical methods of optimisation of individual processes and systems of processes used in the manufacture of molecules. PSE tools include methods of identifying reaction kinetics, methods of model development, model-based design of experiments, analysis of system integration, and system optimisation tools. The application of PSE tools in petrochemical industry is well-developed and leads to major benefits in terms of process efficiency, safety and economics. The application of PSE tools in manufacture of more complex molecules and products, such as agrichemicals and pharmaceuticals, is less developed. This is mainly due to the difficulty in generating good models in the processes that are frequently not fully understood and not fully observed (not all species are monitored or identified). This course will cover key methods from PSE toolbox that are relevant for development of more complex synthetic chemistry-based manufacturing processes: methods of kinetics analysis, model-based design of experiments, use of models for process integration and optimisation. The course will be run as a workshop over two days.

1 other event...

Date Availability
Wed 20 May 2020 09:00 [Places]

Chemistry plays a very crucial role in tackling 21st century global challenges. From climate change mitigation to discovering therapeutic strategies for human health and driving sustainable energy production and usage - we are faced with many challenges for which chemical sciences has been providing and will continue to provide many plausible solutions.

Much of the research involved in developing these initiatives requires a huge drive towards interdisciplinary research networks. As such, this course has been developed with some of our colleagues from across the Chemistry Department who are working on exciting and emerging areas with this multidisciplinary focus.

This 10 session course will introduce how chemistry can be used as a tool to solve these challenges. First session will include the introduction. Each lecture following this will focus on a different branch, area or concept of chemistry covering the fundamental chemistry and background of how it works, any advances to date and the applications towards talking these global challenges.

The first session is compulsory, plus choose optional sessions you wish to attend when you make your booking.

Session 1: Introduction

Session 2: Organic Electronics

Session 3: Electrochemistry (Batteries)

Session 4: Antibody Design

Session 5: Supramolecular Materials

Session 6: Air Quality Sensing

Session 7: Photochemistry

Session 8: Transition Metal Catalysis

Session 9: Mechanochemistry (Mill-Grinding)

Session 10: Bioconjugation

Chemistry: CP1 - Career Options for PhDs Tue 5 May 2020   11:00 [Places]

PhD students have plenty of options once you graduate. In this interactive session we will look at the pros and cons of different career options. You will have a chance to think about what you want your work to do for you and what you can offer employers, and you will learn ways to find out more about jobs in which you are interested.

Starting to apply for jobs both in and outside academia? Preparing for an interview? Not sure how to target your application, what to include and what to leave out. In this session you can learn more about how selection processes work including how to put together a CV and cover letter and how to prepare for job interviews. The workshop will include interactive exercises, a review of successful application materials, and discussions.

Chemistry: DD10 Process Chemistry Workshop new Tue 3 Mar 2020   10:00 [Places]

In this session, Dr. Mukund S. Chorghade will discuss the pivotal role played by Process Chemistry / Route Selection in the progress of a drug from conception to commercialization. The medicinal chemistry routes for synthesis are usually low yielding and are fraught with capricious reactions, cryogenic temperatures, tedious chromatography and problems in scale-up to multi-kilo and multi-ton levels. Considerable research efforts have to be expended in developing novel, cost efficacious and scalable processes and seamlessly transferring these technologies to manufacturing operations. These principles will be exemplified by process development case studies on a variety of pharmaceutical moieties such as anti-epileptic and an anti-asthma drugs. We were able to also discover a large number of New Chemical Entities by our new “Process Chemistry Driven Medicinal Chemistry”

We will exemplify advances in proprietary in vitro green chemistry-based technology, mimicking in vivo metabolism of several chemical entities used in pharmaceuticals, cosmetics, and agrochemicals. Our catalysts enable prediction of metabolism patterns with soft-spot analysis Metabolites are implicated in adverse drug reactions and are the subject of intense scrutiny in drug R&D. Present-day processes involving animal studies are expensive, labor-intensive and chemically inconclusive. Our catalysts (azamacrocycles) are sterically protected and electronically activated, providing speed, stability and scalability. We predict structures of metabolites, prepare them on a large scale by oxidation, and elucidate chemical structures. Comprehensive safety evaluation enables researchers to conduct more complete in vitro metabolism studies, confirm structure and generate quantitative measures of toxicity.

Chemistry: DD3 Modern Tactics to Optimise Potency Fri 24 Jan 2020   14:00 [Places]

When you have 1000s of possible compounds you could make from any one start point what do you make first? This lecture will cover some general basic principles on designing more potent molecules, as well as some practical tips on how to run an optimization program and how to focus synthetic efforts. Binding modalities (reversible, covalent) will be briefly covered, as well as some newer non-traditional modalities. This lecture will also serve as an introduction to the medicinal chemistry game.

Chemistry: DD4 Pharmacokinetics Wed 29 Jan 2020   14:00 [Places]

Predicting and controlling how a chemical molecule will be processed by the body is vital to developing a successful drug. This lecture will discuss the path a molecule takes from initial dose through to elimination, describe the ADME (Absorption, Distribution, Metabolism and Excretion) processes that take place and how these are related to compound structure and physicochemical properties. In addition to standard small molecule PK some other new modalities will be also be introduced to illustrate how methods such as PEGylation and lipoparticle encapsulation can be employed to modulate compound pharmacokinetic properties.

Chemistry: DD5 Medicinal Chemistry Game Workshop Tue 4 Feb 2020   14:00 [Places]

A real drug discovery example will be used. After a brief introduction to the task and the chemical startpoint, we will split into teams and iteratively try to design improved analogues. Molecules will be marked “in real time” during the session to recreate the design-make-test-analysis cycle, then teams can compare their optimized molecules, and we can compare them to what happened in real life.

Please note: To take part in this session you will need to have attended DD1-DD4.

Chemistry: DD6 Toxicity and Drug Safety Fri 7 Feb 2020   14:00 [Places]

Drug safety remains the primary cause of compound attrition when developing new medicines and consequently the ability to understand and predict toxicity is regarded as high priority within the pharmaceutical sector. This lecture will describe some common safety liabilities and ongoing work to build a greater understanding of the relationships between chemical structure and toxicity risk that are being harnessed to guide the design of safer compounds

Chemistry: DD7 Kinase Inhibitor Case Studies Wed 12 Feb 2020   14:00 [Places]

Kinase drug discovery remains to be an area of significant and growing interest across academia and in the pharmaceutical industry - there are approximately 30 FDA approved small molecule inhibitors which target kinases, half of which were approved in the last 3 years. This lecture will give an insight into the medicinal chemistry story behind one clinical candidate and 2 marketed drugs. Crystal structures will be used to explain general principles behind designing for kinase inhibition, and some more advanced topics will be covered such as prodrugs, covalent inhibition and consideration of mutation status in drug discovery