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Fri 14 Feb 2020
13:00 - 15:30

Venue: Todd-Hamied

Provided by: Department of Chemistry

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Chemistry: DD9 Process Chemistry

Fri 14 Feb 2020


Two complementary lecture from industry experts on process chemistry from GSK and Syngenta will share their experiences and challenges gathered over many years of experience.

Target audience
  • All chemistry postgraduates
  • Further details regarding eligibility criteria are available
  • If you are from outside the Department of Chemistry, please wait to be collected from reception

Number of sessions: 1

# Date Time Venue Trainers
1 Fri 14 Feb 2020   13:00 - 15:30 13:00 - 15:30 Todd-Hamied Dr Sabine Fenner,  Dr George Hodges
A GSK Case Study - Dr S Fenner

As potential new drugs approach launch there is an ever-increasing application of the tools of process chemistry (statistical experimental design, reaction kinetics, in-situ reaction monitoring etc) in order to define a control strategy that provides a thoroughly understood, robust reaction sequence that can be used to manufacture the drug to acceptable quality on an ongoing basis. This control strategy also forms a key part of any regulatory submission required before the drug can be sold. This lecture will present a recent case study on the process development carried out on a real GSK drug molecule and demonstrate the tools and approaches employed as the control strategy evolved.

Recommended text: Lee, S. and Robinson, G. Process Development: Fine Chemicals from Grams to Kilograms (Oxford Chemistry Primers); OUP: Oxford, 1995

What Influences a Reaction? - Dr G Hodges

Scale up is made complex by the fact that some parameters change while others remain constant. Successful scale up therefore requires an understanding of the reaction “driving force” and how it changes as a function of scale. This talk will go through building up a fundamental understanding of a reaction from both a chemical and engineering point of view and show how this can not only help in scaling-up, but can also be used to influence lab scale reactions in ways usually ignored.

Recommended text: Atherton, J. and Carpenter, K., Process Development - Physicochemical Concepts (Oxford Chemistry Primers) ; OUP: Oxford, 2000.

  • One session of one and a half hours
Related courses
Drug Discovery

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